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National Drug Codes (NDC) and Medisoft (v17)

Along with the 5010 ANSI implementation, many providers are now being required to provide additional information for the drugs they prescribe.  We are going to focus on Medisoft v17+, because even though most of this information can be applied to older versions, only v17+ will has the supported parts which will allow for 5010 ANSI transmission of the NDC.


NDCs are additional codes added to procedures to signify the type, quantity and method of the drug administered.  Matching procedure codes to appropriate NDCs can be a trying process, but we will discuss more about this later in the tutorial.  First we'll start by showing where NDC is applied in Medisoft and then we will go more into how to find the information to fill these locations.


In Medisoft, open a procedure code from the procedure list (Lists->Procedure/Payment/Adjustment Codes->Edit/Create New Procedure Code)



Code 1=the main reference code of this procedure

Description=normally will be the short description of the drug which usually includes (but not limited to) Name/Brand/Type/Dosage

Alternate Codes=optional code sets (helpful if you have a procedure code 1 which may use more than one NDC, setting the carriers required to use Code set 2 or 3 will allow for this situation i.e.. J0490 and MJ0490 use different NDCs however both their code set 2s are set to J0490, the carrier is set to use code set 2 so in billing to the carrier J0490 will appear as the procedure but will use the NDC based on either using code 1 J0490 or code 1 MJ0490)

National Drug Code=sets the default NDC of this procedure

NDC Unit Price=sets default unit price for this NDC

NDC Unit of Measurement=sets the default unit of measurement for the NDC (note requirements for billing may differ from actual drug unit of measurement (i.e. drug may be in mg's but may need to be billed as 1mg=1Unit))

Code ID Qualifier=no longer needed for NDCs (i.e. remove N4 if present)


After these settings have been defined under the procedure code, when it is used in transactions from this point forward the additional NDC information will be added to the transaction lines as defaults for this code.  (Note: if you update an NDC code for a procedure code, you must update the transaction line details of any previously created transaction, if it still needs to be billed, otherwise it may contain the pre-update data or none at all, checking the transaction or claim before it goes out is the safest method for billing)



We recommend you add the NDCCode, NDCUnitCount, NDCUnitMeasurement, NDCUnitPrice, Procedure Description and the transaction Description fields to the transaction entry screen in Medisoft to facilitate adding additional information when entering information through transaction entry.  This information can also be set for the transaction line by selecting the "Details" button, while the line is selected.



For paper claims you may be required to copy the Procedure Description field to the Description (transaction) field, because paper claims require both the NDC and the short drug description in the space above the transaction line on the claim form.


For ANSI 5010; Loop2400-SV1 and 2410 will contain the information relating to the procedure code and NDC information.  Which would be similar to the following if the above transaction line information was used:


SV1*HC:J0490:::::BENADRYL HCL, UP TO 50 MG.*4999.5*UN*1***1:2:3






We have found one of the most difficult things about billing procedures with NDCs is matching up the correct NDC to bill with the appropriate information.  Below we have listed some of the ways we have found to make this process easier, however in some cases (most, really) you will end up having to bill the procedure w/ code and details to find out if it will pay correctly by that specific carrier.  Different carriers may have different requirements for the Procedure Code, NDC or its additional information, normally you can base the majority of your information on Medicare's requirements but this may not always apply with other carriers.


The first thing is to try to find out as much as you can about the procedure code, the drug you are using and any other information from the carrier you are trying to bill or the Representative/Distributor of the particular drug itself.  This can be tedious, especially if you are just getting started billing out NDCs for a practice that has been billing previously or has a large number of procedure codes that require NDC.  This process, although trying maybe actually faster than the other option which is to bill out and wait for a payment or denial and then possibly have to re-bill with different information.  Majority of the time the carrier is not going to be able to tell you prior to billing the code at least once, in my experience at least.  Check with the carrier or on their site for an HCPCS-NDC-J-Code Crosswalk which would provide you with all the information you need specific to that carriers requirements.  Most do not offer this very helpful tool, but Noridian does and have been keeping it up to date month to month in 2012.

Noridian's NDC-HCPCS Crosswalk -

Or you can use the FDA's NDC search or even download their database information and use that if you wish.

The FDA NDC Search will normally return the 10-digit NDC, since an 11-digit NDC is required for billing purposes, you can add leading-zeros (ex. 123456789 would be 00123456789)


You can normally find an 11-digit NDC number printed on the drug package in a 5-4-2 format. The first five digits of the NDC identify the drug manufacturer, the next four identify the specific product and the last two identify the package size.   You may be able to use this knowledge to further your search for the correct NDC if the code on the drug package is not the appropriate NDC to bill under the procedure/diagnosis on the claim.


If you can easily find the code/NDC Noridian's crosswalk, use the FDA search to find the drug and then try to find the result on the crosswalk would be the best route to take.


Once the drug is found on the crosswalk, you will have you J-Code, NDC, short description, Unit of Measurement and Unit count.  The unit of measurement and unit count can vary depending on the carrier, however we have found most carriers require the Unit of Measurement to be "Units" and the Unit count to be the amount of "Units" per "transaction/dose".  (ex 50Mg of DrugA=Unit of Measurement will be 'Unit'  where 1Mg=1Unit & Unit Count will be '50'.  The transaction would then have only 1 unit on the 'Units to bill' because the drug dose of 50Mg was only administered once.


The next part will be calculating the Unit Price.  This can be determined by taking the amount you normally charge for this procedure and dividing it by the Unit Count.  (ex. Practice charges $4999.5 for each J0490 procedure they perform.  Since this J-code is administered in 50ml it is equal to 50 Units for Unit Count.  Divide the Unit Price by the Unit Count, 4999.5/50=99.99; so the Unit Price of this procedure is $99.99)


You should check with the Carrier you are trying to bill to or your drug's representative for more information about the Unit Price or anything else discussed in this tutorial not directly relating to Medisoft's data entry.   For any and all other questions you may contact Medical Data Solutions support for more information or training if you would like.


All the information used as examples in this tutorial are purely fictional and any relation to actual medical information or billing is purely coincidental. 

Please use this tutorial's information for reference purposes only!

If you have any further questions or would like to know more about the NDCs and Medisoft:

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